Which statement accurately describes a potential issue for responders in large buildings?

The correct statement highlights that large buildings can indeed create fatigue issues for responders. In emergency situations, responders may need to traverse extensive areas and navigate complicated layouts, which can lead to physical exhaustion. The scale of large buildings often means longer distances must be covered, and responders may face obstacles such as stairwells, crowded hallways, or smoke-filled environments. This physical demand, combined with the mental stress of dealing with emergencies, can significantly contribute to fatigue.

In contrast, the other statements are inaccurate. Large buildings typically feature complex and multifaceted floor plans that can confuse responders rather than simplify the navigation process. Additionally, smoke in large buildings does not uniformly disperse, often leading to visibility challenges and hazardous conditions that complicate movement. Many large buildings are also equipped with fire suppression systems, such as sprinklers, which are designed to mitigate the risk of fire spread and enhance safety for both occupants and responders.